FindTrial
Sign In

Usefulness of balanced salt solution versus ringer lactate on postoperative renal parameters and arterial blood gas analysis in patients with hypertension on angiotensin receptor blockers or angiotensin converting enzyme inhibitors in surgeries under general anaesthesia

Evaluation of the intra operative use of balanced salt solution versus lactated ringers solution on postoperative arterial blood gas analysis and renal function indicators in patients with primary hypertension treated with angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) in elective surgeries under general anesthesia - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/05/067545
Enrollment
50
Registered
2024-05-17
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I10- Essential (primary) hypertension Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Group P: Patients receiving plasmalyte as sole intravenous fluid of choice intra operatively and for 24 hours after extubation Intervention2: Group Ringers lactate: Patients receiving r

Sponsors

Dr Nishanth M
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade 1 and 2 Age 18-60 years Both genders Elective surgeries under general anaesthesia of not more than 240 mins in duration Known case of essential hypertension since more than 2months on angiotensin convertase inhibitor or angiotensin receptor blocker medication

Exclusion criteria

Exclusion criteria: ASA grade 3and 4 Patients on diuretics Patients on beta blockers Patients on non-steroidal analgesics Patients with congestive heart failure Patients with renal artery stenosis Patients with atherosclerosis, thrombosclerosis Patients with excessive preoperative fluid deficit due to gastrointestinal fluid loss

Design outcomes

Primary

MeasureTime frame
To compare serum potassium and eGFR in the immediate postoperative period in both the groups with baselineTimepoint: Serum potassium and eGFR within 1 hour and after 24 hours after extubation—

Secondary

MeasureTime frame
To compare perioperative urine output in both the groups.Timepoint: 24 hours urine output after extubation;To compare postoperative serum chloride levels on arterial blood gas analysis in the immediate postoperative period in both the groups With baselineTimepoint: Serum chloride levels within in 1 hour and after 24 hours of extubation;To compare serum lactate levels in the plasmalyte group with those in the Ringer’s Lactate group at different time intervals with baselineTimepoint: Serum lactate levels within 1 hour and 24 hours after extubation;To compare serum pH and standard base excess on arterial blood gas analysis in the immediate postoperative period in both the groupsTimepoint: Serum pH and standard base excess measurement at baseline, within in 1 hour and 24 hours after extubation—

Countries

India

Contacts

Public ContactDr Nishanth M

Nizams institute of medical sciences

abhiruchipatki2204@yahoo.co.in9177909339

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026