Health Condition 1: K859- Acute pancreatitis, unspecified
Conditions
Interventions
Intervention1: Rectal Indomethacin Suppository: Patients with mild and moderate acute pancreatitis treated with rectal indomethacin suppositories.
The patients in this arm will receive a loading dose
Sponsors
Jawaharlal Institute of Postgraduate Medical Education and Research JIPMER Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. abdominal pain, characteristic of acute pancreatitis 2. Serum amylase or Lipase values more than three times the upper limit of normal 3. Characteristic findings of acute pancreatitis on abdominal ultrasound or CT scan. 4. Patients diagnosed with SIRS syndrome within 72 hours of admission. 5. Mild and moderate pancreatitis according to revised Atlanta classification and BISAP SCORING SYSTEM
Exclusion criteria
Exclusion criteria: 1. Presence of organ failure on admission 2. Pregnancy. 3. Allergy to non-steroidal anti-inflammatory drugs. 4. Active peptic ulcer disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the change in systemic inflammatory response syndrome score(SIRS) from Admission to 48 hours & after intervention with rectal indomethacin suppositoryTimepoint: 1. at the time of admission followed by 24 hours, 48 hours & 72 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. to measure C-reactive protein levels. 2. Change in SIRS scores at 24 and72 hours. 3. Development of organ failure. 4. Length of ICU stay. 5. Length of hospitalisation. 6. Acute pancreatitis SeverityTimepoint: 1. at the time of admission followed by 24 hours, 48 hours & 72 hours. | — |
Countries
India
Contacts
Public ContactDr. Vikash K
JIPMER(Jawaharlal Institute of Post graduate Medical Education and Research)
Outcome results
None listed