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A Clinical trial to study the effect of adding neostigmine to local anaesthetic ropivacaine for painless upper limb surgeries

Effect of adding neostigmine to ropivacaine for supraclavicular brachial plexus block in upper limb surgeries; a randomized, double blinded study - NIL

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/05/067489
Enrollment
84
Registered
2024-05-16
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: S699- Unspecified injury of wrist, handand finger(s)

Interventions

Intervention1: Neostigmine: 0.5% Neostigmine 1ml as an additive to 0.75% ropivacine 20ml for supraclavicular block given once during block administration for a maximum duration of 15 mins and monitore

Sponsors

M S Ramaiah Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists Physical status 1,2 and 3 undergoing elective upper limb surgeries.

Exclusion criteria

Exclusion criteria: Refusal to consent for the proposed study Infection at injection site History of any bleeding tendency, was taking oral anticoagulants(INR more than 1.5) Brachial plexus-related neurological deficits Allery to study drug Chronic or Acute inflammatory conditions Long term opioids/analgesics usage Severe pulmonary/cardiac/hepatic disease Epilepsy Bronchial asthma

Design outcomes

Primary

MeasureTime frame
To assess onset and length of sensory and motor blockadeTimepoint: 2,4,6,8,10,12,14,16 minutes and upto 24 hours for length

Secondary

MeasureTime frame
To assess the intraoperative analgesic usage and postoperative analgesic need.Timepoint: 24 hours;To determine first analgesic request time and 24 hour total analgesic dosageTimepoint: 4,8,12,16,20,24 hours;To monitor occurrence of any side effectsTimepoint: 24 hours

Countries

India

Contacts

Public ContactDr Navdeep

M S Ramaiah Medical College

nvdepkaur@gmail.com9945557290

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026