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Comparative evaluation of clinical performance of adhesive restorations with and without pretreatment of tooth substrate with MMP inhibitors- A split mouth randomised controlled trial.

Tooth surface pretreatment with MMP inhibitor on clinical performance of adhesive restorations- A split mouth randomised clinical trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/05/067412
Enrollment
62
Registered
2024-05-15
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K025- Dental caries on pit and fissure surface

Interventions

Intervention1: 0.2% PHMB: 0.2% PHMB will be used for pretreatment of cavity after etching and followed by dentin bonding agent and composite restoration. This experimental group will be compared to co

Sponsors

Dr Vishakha Kumar Mendiratta
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Primary carious Class I lesions in the permanent molar teeth requiring restoration 2. Participants should have atleast two class 1 cavities on both sides in permanent molars scored as code 5 according to International Caries Detection and Assessment System (ICDAS) 3. Participants of age group 18-50 years will be included with good oral hygiene and general health 4. Participants with posterior tooth with no periapical pathology or symptoms of irreversible pulpitis 5. Patients with healthy periodontium

Exclusion criteria

Exclusion criteria: Patient related 1. Participants younger than 18 years 2. Pregnant ladies, smokers and participants with medical complications are not included 3. Patients with periodontitis 4. Patients with xerostomia 5. Bruxers 6. Patients incapable to undergo rubber dam isolation Tooth related 1. Teeth with pulpal or periapical pathology 2. Endodontically treated teeth 3. Absence of occlusal contact with antagonists teeth 4. Attrition and erosion 5. Fixed or removable prosthetic tooth as antagonist

Design outcomes

Primary

MeasureTime frame
There will be difference in clinical performance of composite restoration in teeth pretreated with 0.2% PHMB and teeth not pretreated with 0.2% PHMB. Timepoint: follow up after 3,6,9,12 and 15 months—

Secondary

MeasureTime frame
There will be no difference in clinical performance of composite restoration in teeth pretreated with 0.2% PHMB and teeth not pretreated with 0.2% PHMB. Timepoint: follow up after 3,6,9,12 and 15 months—

Countries

India

Contacts

Public ContactDr Vishakha Kumar Mendiratta

Manav Rachna Dental College

sonalsoi83@gmail.com8979266934

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026