Health Condition 1: I08- Multiple valve diseases
Conditions
Interventions
Intervention1: Injection Dexmedetomidine: Infusion of Inj Dexmedetomidine IV at 0.6MCG/kg/hr in 50 ml syringe 10 minutes before induction to 6 hours after surgery.
Control Intervention1: Normal saline
Sponsors
SMS Medical College and Hospitals
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients willing to give consent. 2. Patients of 18 to 80 years of age scheduled for cardiac valve replacement/valvuloplasty with either a single valve or multiple valves under CPB. 3. ASA grade 2 and 3.
Exclusion criteria
Exclusion criteria: 1.Non-cooperative patient. 2.Patients with BMI more than or equals to 30kg/m2. 3. Patients with pre-op pulmonary infection, liver insufficiency, kidney insufficiency. 4. Patients with history of use of nephrotoxic drugs and contrast agents used within 48 hours. 5. Patients with history of kidney or heart surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of Mean changes in renal function pre-op and post op 48 hrs after surgery by measuring Serum Creatinine and Blood Urea.Timepoint: Comparison of Mean changes in renal function pre-op and post op 48 hrs after surgery by measuring Serum Creatinine and Blood Urea. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Comparison of Mean changes in Intraoperative Haemodynamics (MAP and HR). 2.Comparison of Mean Changes in serum indices C reactive protein levels in both the groups. 3.Comparison of Mean Changes in postoperative recovery and incidence of complications.Timepoint: 1.30min interval throughout surgery. 2.48 to 72 hours after surgery. | — |
Countries
India
Contacts
Public ContactDr Tejaswini H J
Sawai Man Singh Medical College and Hospitals
Outcome results
None listed