To study the correlation of pre emptive analgesia with ibuprofen with post operative IL-6 levels in patients undergoing elective surgeries under general anaesthesia.

Effect of pre-emptive analgesia with ibuprofen on post operative interleukin 6 levels in patients undergoing elective surgical procedure under general anaesthesia. - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/067317

Enrollment

Registered

2024-05-14

Start date

Unknown

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Iv Ibuprofen: administering Iv Ibuprofen 400mg 30 minutes before the surgery in the test group. Control Intervention1: Normal saline: Normal saline will be administered intravenously 30

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing elective surgery of duration less than 120 minutes under general anaesthesia

Exclusion criteria

Exclusion criteria: 1.Refusal of patients for taking part in the study 2.Patients allergic to ibuprofen 3.Patients with thrombocytopenia 4.Patients with renal impairment 5.Patients with gastric ulcers 6.Patients with severe cardiac, renal and neurological issues. 7.Patients unable to comprehend the post operative pain scores 8.Patients with lateral sinus/ sigmoid sinus/ cavernous sinus thrombosis, petrous apicites, brain abscess

Design outcomes

Primary

Measure	Time frame
To evaluate the effect of pre emptive analgesia with ibuprofen on post operative IL-6 levels in patients undergoing elective surgeries under general anaesthesia.Timepoint: baseline and at 6 hours after the surgery	—

Secondary

Measure	Time frame
1.To determine IL6 levels in the preoperative and post operative period and draw correlation between them 2.To calculate the time to first analgesic request and total cumulative dose of post operative analgesic over 24 hours 3.To evaluate post operative VAS scores and post operative nausea and vomiting at stipulated time intervals 4.Note any side effect pertaining to the drug administered. 5.To evaluate post operative hemodynamicsTimepoint: baseline,30 minutes,60 minutes, 6 hours, 12 hours, 24 hours	—

Measure

Time frame

1.To determine IL6 levels in the preoperative and post operative period and draw correlation between them 2.To calculate the time to first analgesic request and total cumulative dose of post operative analgesic over 24 hours 3.To evaluate post operative VAS scores and post operative nausea and vomiting at stipulated time intervals 4.Note any side effect pertaining to the drug administered. 5.To evaluate post operative hemodynamicsTimepoint: baseline,30 minutes,60 minutes, 6 hours, 12 hours, 24 hours

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Countries

India

Contacts

Public ContactDr Richa Saroa

Government medical college and hospital,Sector-32,Chandigarh

sanjeev_palta@yahoo.com9646121523

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026