Health Condition 1: K802- Calculus of gallbladder without cholecystitis Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: Intraperitoneal Dexmedetomidine(IP): Each patient will receive intravenous 50 ml normal saline over 10
minutes when the surgeon initiates dissection of the gall bladder and intraperito
Sponsors
University College of Medical Sciences and Guru Teg Bahadur Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Consenting male or female patients aged 18-60 years scheduled for elective Laparoscopic cholecystectomy under general anaesthesia. 2. Belonging to ASA grade I or II
Exclusion criteria
Exclusion criteria: 1. Patients with abnormalities like heart block, conduction defect in pre-operative ECG 2. Patients with known allergies to the study drugs 3. Obese patients (BMI = 30) 4. Patients in whom subhepatic drain is inserted after gall bladder removal
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of time for extubation in the two groups.Timepoint: Time taken from administration of reversal drug to removal of endotracheal tube | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare between the two groups various inflammatory markers such as:- i) IL-6 ii) CRP iii) S. Cortisol iv) S. Albumin v) Blood Glucose Timepoint: pre-operative and six hours post induction;To compare between the two groups – 1.Time to discharge from PACU using Modified Aldrete score. 2. Hemodynamic parameters at the time of extubation 3 Post-operative pain using Numeric Rating Scale (NRS) Timepoint: post operative;To compare between the two groups – Amount of rescue analgesia required in 24 hoursTimepoint: 24 hours post operative | — |
Countries
India
Contacts
Public ContactDr Ashish Garg
UCMS and GTB hospital
Outcome results
None listed