Health Condition 1: F840- Autistic disorder
Conditions
Interventions
Intervention1: repetitive transcranial magnetic stimulation-iTBS: iTBS - bursts of 3 pulses at frequency of 50 Hz every 200 ms 2 s of TBS trains (30 pulses) are repeated every 10 s for 190 s, with a t
Sponsors
AIIMS, New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: Social Quotient more than 70 Meeting DSM 5 criteria for ASD Right handed Parents willing to give written informed consent for participation in the study Children willing to give assent Patients stable on psychotropic medication for a period of at least 2 months
Exclusion criteria
Exclusion criteria: Social Quotient less than 70 or mild moderate or severe intellectual disability, or any other comorbid psychiatric syndrome diagnosis or substance use disorder History of seizure History of receiving any treatment with brain stimulation Parents not willing for participation in study Presence of unstable medical illness Reported History suggestive of space occupying brain lesion or cerebrovascular accident Having implanted device or metal in brain head or cardiac pacemaker or ferromagnetic dental braces
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the improvement of social relationships and reciprocity, emotional responsiveness, speech and language communication, behavior patterns, and sensory aspects of ASD after rTMS in children and adolescents with simultaneous Applied Behavior Analysis TherapyTimepoint: 1 week before rTMS (pre rTMS) Post rTMS: 3 weeks, at 4 weeks and 12 weeks follow up. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the persistence in improvement post rTMS at 1month and 3month intervals and assess safety with adverse event reporting.Timepoint: At 4 weeks and 12 weeks | — |
Countries
India
Contacts
Public ContactShaheen Sithara S
All India Institute of Medical Sciences New Delhi
Outcome results
None listed