Comparative study between intravenous remifentanil and intravenous fentanyl in controlling blood pressure, Heart rate in patients undergoing General Anaesthesia.

A Comparative study between Remifentanil and Fentanyl in attenuation of hemodynamic response to Laryngoscopy and Tracheal Intubation in patients undergoing General Anesthesia requiring Endotracheal Intubation– A double blinded randomized controlled trial. - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/067293

Enrollment

Registered

2024-05-14

Start date

Unknown

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Injection Remifentanil: Injection Remifentanil 2mcg/kg IV diluted in 5ml saline given over one minute , 2 minutes before intubation. Intervention2: Injection fentanyl: Inj. Fentanyl 2mc

Eligibility

Inclusion criteria

Inclusion criteria: Age 18 – 60 years of either sex. American society of Anesthesiologist 1 and 2 patients. (ASA 1 – A normal healthy patient, ASA 2 – A patient with mild systemic disease).

Exclusion criteria

Exclusion criteria: Patients undergoing emergency surgeries. 2. Pregnant women 3. Patients with uncontrolled hypertension 4. Cardiovascular and cerebrovascular disease 5. Known allergy to study drug 6. Anticipated difficult intubation. 7. Patients on beta blockers

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of bolus dose of remifentanil (2µg/kg) and bolus dose of fentanyl (2µg/kg) in attenuating heart rate response to laryngoscopy and intubation in patients undergoing General Anesthesia.Timepoint: The hemodynamic parameters like heart rate , systolic blood pressure , diastolic blood pressure , mean arterial pressure will be measured and recorded at 0, 1 , 2 , 3, 4, 5 minutes and every 5 minutes for the next 30 minutes and every 15 minutes thereafter till the end of surgery	—

Measure

Time frame

To compare the efficacy of bolus dose of remifentanil (2µg/kg) and bolus dose of fentanyl (2µg/kg) in attenuating heart rate response to laryngoscopy and intubation in patients undergoing General Anesthesia.Timepoint: The hemodynamic parameters like heart rate , systolic blood pressure , diastolic blood pressure , mean arterial pressure will be measured and recorded at 0, 1 , 2 , 3, 4, 5 minutes and every 5 minutes for the next 30 minutes and every 15 minutes thereafter till the end of surgery

—

Secondary

Measure	Time frame
To compare the incidence of complications (bradycardia, hypotension, hypertension) between both the groupsTimepoint: Patient’s hemodynamic parameters like Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure will be checked every minute for the initial 5minutes and every 5 minutes for next 30 minutes and every 15 minutes thereafter till the end of surgery.	—

Countries

India

Contacts

Public ContactDr D Merlin Lydia

Pondicherry Institute of Medical Sciences

siva85dr@gmail.com9944060676

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026