Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: LABETOLOL: Labetalol 0.25mg/kg in 10ml normal saline iv over 10min 5min before induction of anesthesia
Control Intervention1: Dexmedetomidine: Dexmedetomidine 1 µg/kg in 10ml normal sal
Sponsors
Dr Ambati Mounika
Eligibility
Inclusion criteria
Inclusion criteria: 1 Patients of ASA grade 1 and 2 who are undergoing elective surgery under general anesthesia 2 Patients who consent to participate in the study 3 Patients having informant available
Exclusion criteria
Exclusion criteria: 1 Difficult airway 2 Hypertension 3 Diabetes mellitus 4 ischemic heart disease 5 renal diseases 6 Cerebrovascular Disease • Patients on beta blockers alpha blockers • Bronchial asthma • Allergy to study drug
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dexmeditomidine 1µ/Kg given slowly over 10 minutes intravenously 5 minutes prior to induction, attenuates the cardiovascular responses to laryngoscopy and intubation in a better manner than Labetalol 0.25mg/Kg.Timepoint: post intubation vitals are measured every 3minutes for first 15minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| To observe the effect of Dexmedetomidine in attenuating the hemodynamic stress response during Laryngoscopy and intubation 2)To observe the effect of labetalol in attenuating hemodynamic stress response during Laryngoscopy and Intubation 3)To compare between Dexmedetomidine and Labetalol in the specified dosage. Timepoint: post intubation vitals are measured every 3minutes for first 15minutes | — |
Countries
India
Contacts
Public ContactDr U Sankar Rao
Dr Pinnamaneni Siddhartha Institute of Medical sciences and Research Foundation
Outcome results
None listed