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Mapping lymphatic drainage patterns in recurrent oral cavity squamous cell carcinoma using sentinel lymph node biopsy.

Utilizing sentinel lymph node biopsy to identify the lymphatic drainage pattern in clinically node negative recurrent oral cavity squamous cell carcinoma. A feasibility study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/05/067253
Enrollment
30
Registered
2024-05-13
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx

Interventions

Intervention1: Technetium 99 nanocolloid: Dose- 0.2ml Route - peritumoral Frequency - once Duration - 30min Control Intervention1: NIL: NIL

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Biopsy proven recurrent or second primary invasive squamous cell carcinoma of oral cavity on the side which has previously been treated with neck dissection or radiation 2 Clinicoradiologically T1, T2, T3 tumors with node negative disease and no distant metastases on whole body PET CECT 3 Planned for curative intent surgical excision of the primary tumor with elective neck dissection of the contralateral side

Exclusion criteria

Exclusion criteria: 1 Patients with reduced mouth opening where peritumoral injection of radiotracer along 4 quadrants not possible 2 Patients who are not suitable for curative intent surgery or neck dissection for medical or surgical reasons 3 Patients in whom bilateral neck dissection has been done in the previous surgery

Design outcomes

Primary

MeasureTime frame
To identify the patterns of lymphatic drainage patterns in patients with recurrent OSCC with previously treated neckTimepoint: 1 Month—

Secondary

MeasureTime frame
To assess the sensitivity, specificity, positive and negative predictive value of SLNBTimepoint: 1 Month;To study the accuracy of PET CECT and SLNB for detection of LN metastases in recurrent OSCC as compared to the final histopathology reportTimepoint: 1 Month—

Countries

India

Contacts

Public ContactDr Vidisha Tuljapurkar

Tata Memorial Hospital

latikakansal@gmail.com24177000

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026