To study and compare lignocaine and ketofol in reduction of intracranial and intraocular pressures while suctioning the airway of tracheostomized head injury patients

Comparison of lignocaine and ketofol for attenuation of rise in intracranial pressure in response to tracheal suctioning in head injury patients - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/067235

Enrollment

Registered

2024-05-13

Start date

Unknown

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 4- Measurement and Monitoring

Interventions

Intervention1: Comparison of changes in Intracranial pressure and Intraocular pressure at and within 10 minutes of suctioning: Comparison of changes in Intracranial pressure and Intraocular pressure w

Eligibility

Inclusion criteria

Inclusion criteria: 50 adult patients age group 18-60 years who have sustained head injury and mechanically ventilated in ICU.

Exclusion criteria

Exclusion criteria: Requirement of high PEEP, Ocular trauma, ocular fracture, Allergy to study drug, Presence of Chest injury, Hemodynamically instability, Oxygen saturation less than 90, Decompressive craniotomy, History of severe cardio respiratory disorders, Pregnancy and lactation

Design outcomes

Primary

Measure	Time frame
Intracranial pressure by measuring optic nerve Sheath diameterTimepoint: Base Line, Before Suctioning, After suctioning (5 minutes), After suctioning (10minutes)	—

Secondary

Measure	Time frame
Intraocular pressureTimepoint: Base Line, Before Suctioning, After suctioning (5 minutes), After suctioning (10minutes)	—

Countries

India

Contacts

Public ContactDr Sarveshwar

Pt.B.D.Sharma PGIMS, Rohtak

sharma.sarveshwar312@gmail.com8168550175

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026