Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Extended Oral antibiotic for 7 days: Extended prophylaxis: This involves administering oral antibiotics for longer than 24 hours, for 7 days.
Third generation cephalosporin (Cefdinir,
Sponsors
KIMS Sunshine Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients undergoing primary total hip and total knee arthroplasty. 2. Age between 18 and 80 years 3. No known contraindications to extended antibiotic use like allergy or hypersensitivity.
Exclusion criteria
Exclusion criteria: 1. Known allergy to Cephalosporins/Doxycycline. 2. History of recent systemic/ local infection 3. Concurrent systemic infections 4. h/o previous knee/ hip surgeries. 5. h/o prior intra-articular injections within 3 months 6. Inflammatory, post-traumatic arthritis 7. Patients on immune-suppressive medications including anti-cancer drugs, and steroids.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Outcome: 1. Incidence of PJI and surgical site infections within the 90-day postoperative period- based on 2018 MSIS- ICM criteria 2. Incidence of Surgical Site Infection 3. Incidence of Reoperation- due to any cause 4. Incidence of stitch abscess Timepoint: 2 weeks, 4 weeks, 8 weeks, 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary Outcomes: Need for repeat oral antibiotic within follow-up duration Types of pathogens causing infections Rates of antibiotic resistance among isolated pathogens Adverse effects related to extended antibiotic use Timepoint: 2 weeks, 4 weeks, 8 weeks, 12 weeks | — |
Countries
India
Contacts
Public ContactRonak Kothari
Sunshine Bone and Joint Institute, KIMS - Sunshine Hospitals
Outcome results
None listed