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A study compares the effects of Dexmedetomidine administered via trachea versus vein on recovery process and peri-extubation cough prevention. Patients and evaluators remain unaware of treatment assignment

Comparison of effect of low dose intratracheal and intravenous dexmedetomidine administration on recovery from general anaesthesia after abdominal surgery: a randomised double blinded study - NIL

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/05/067165
Enrollment
90
Registered
2024-05-10
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis

Interventions

Intervention1: Intratracheal dexmedetomidine: The medications tagged with the study group, administered intratracheally half hour before the end of the surgery Dex (0.3mcg/kg, diluted and mixed in 2mL

Sponsors

Dr S N Medical college
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Individuals of both genders aged between 18 and 60 years, with a weight falling within the range of 40 to 80 kg with physical status American Society of Anaesthesiologists (ASA) I and II, undergoing elective abdominal surgery under general anaesthesia will be included.

Exclusion criteria

Exclusion criteria: 1) Long term use of sedative drugs (benzodiazepines, barbiturates), 2) Anticipated difficult airway, 3) Those who received alpha2 agonists preoperatively, 4) Patients who were transferred to open surgery during the operation were excluded from the final analysis.

Design outcomes

Primary

MeasureTime frame
The primary outcome will include severity of cough at extubation assessed by 4 point cough scaleTimepoint: 0 minutes, 2 minutes, 5 minutes, 15 minutes, 30 minutes post extubation

Secondary

MeasureTime frame
Monitoring of hemodynamic parametersTimepoint: 5 min before anaesthesia(T0), immediately after administration of dexmedetomidine(T1), 5 min after DEXMEDETOMIDINE(T2), 10 min after DEXMEDETOMIDINE(T3), at end of surgery(T4), at awareness(T5), at extubation(T6), 2 min after extubation(T7), 5 min after extubation(T8), 15 min after extubation(T9), 30 min after extubation(T10)

Countries

India

Contacts

Public ContactDr Piyush Nawal

Dr S N Medical college

piyushnawal30@gmail.com9518739860

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026