Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Hydrocortisone: 200 mg/day over 7 days period
Control Intervention1: Hydrocortisone: 200 mg/day as conventional bolus therapy (50-mg IV bolus diluted in 5ml normal saline every 6 hours)
Sponsors
University College of Medical Siences
Eligibility
Inclusion criteria
Inclusion criteria: Patients diagnosed to have sepsis requiring norepinephrine for blood pressure maintenance
Exclusion criteria
Exclusion criteria: Known case of cardiac dysfunction, diabetes, on steroid therapy prior to illness, received etomidate, on vasopressors for more than 24 h before ICU admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Shock resolutionTimepoint: once, at 7 days after recruitment | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of vasopressor therapyTimepoint: Once;Average daily blood glucoseTimepoint: 4 hourly;Average daily insulin requirementTimepoint: 4 hourly;Recurrence of new episode of septic shock after 24-hour discontinuation of vasopressorsTimepoint: Once, after 24-hour discontinuation of vasopressors | — |
Countries
India
Contacts
Public ContactDr Rashmi Salhotra
University College of Medical Sciences, Delhi
Outcome results
None listed