A study where patients undergoing surgeries of liver and gallbladder will be exposed to different gases of anesthetic agents during the operation

A Randomized Controlled Trial of Recovery Profile when Switching From Isoflurane to Sevoflurane or Desflurane in Patients Undergoing Elective Non-Malignant Hepatobiliary Surgeries under General Anaesthesia - NIL

Status

Recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/067116

Enrollment

Registered

2024-05-09

Start date

Unknown

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Switching from isoflurane to desflurane before closure is started.: This group of people will have oxygen (33%), nitrous oxide (67%) and isoflurane 0.5MAC till closure of muscular layer

Eligibility

Inclusion criteria

Inclusion criteria: 1. All patients undergoing elective non-malignant hepatobiliary surgeries 2. ASA I, II patients

Exclusion criteria

Exclusion criteria: Severe ischemic heart disease, coagulopathy, chronic obstructive pulmonary disease, neuromuscular disorders Pregnant and lactating mothers Body mass index more than 30kg/m2 Allergy to drugs used in study or history of malignant hyperthermia in the family Any event other than switching inhalational drugs which cause their stoppage during study Surgery duration less than 90minutes or more than 3 hours

Design outcomes

Primary

Measure	Time frame
Recovery profile after recovery from general anaesthesia based on CAM score (Confusion assessment score) where 0-2 means no delirium, 3-5 means mild to moderate delirium and 6-7 means severe delirium Timepoint: Outcome will be assessed at: After surgery at extubation, 1,2,4,6,8,10,15,20,25,30,45,60,75,90 and 120 minutes post extubation	—

Secondary

Measure	Time frame
Monitoring hemodynamic parameters and recovery parameters in the intraoperative and post-operative period like mean arterial pressure, heart rate, SpO2, respiratory rate, tidal volume, MAC, PEEP and ETCO2 in the intra operative period and Mean arterial pressure, heart rate, SPO2, Respiratory rate, VAS score and Ramsay sedation score, GCS and Post operative nausea and vomiting in the post operative periodTimepoint: 1. Intraoperative time points are: 0,3,6,9,12,15,18,21,24, 27,30,35,40,45,50,55,60,65,70,75,80,85,90,95,100,105,110,115,120,125,130,135,140,145,150,155,160,165,170,175,180 minutes 2. Post operative time points are: 1,2,4,8,12,24 hours	—

Measure

Time frame

Monitoring hemodynamic parameters and recovery parameters in the intraoperative and post-operative period like mean arterial pressure, heart rate, SpO2, respiratory rate, tidal volume, MAC, PEEP and ETCO2 in the intra operative period and Mean arterial pressure, heart rate, SPO2, Respiratory rate, VAS score and Ramsay sedation score, GCS and Post operative nausea and vomiting in the post operative periodTimepoint: 1. Intraoperative time points are: 0,3,6,9,12,15,18,21,24, 27,30,35,40,45,50,55,60,65,70,75,80,85,90,95,100,105,110,115,120,125,130,135,140,145,150,155,160,165,170,175,180 minutes 2. Post operative time points are: 1,2,4,8,12,24 hours

—

Countries

India

Contacts

Public ContactDr Anusree Paul

Midnapore Medical College & hospital

sumanc24@gmail.com983024881

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026