Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Correlation of polymorphisms in candidate genes with dose variability and cardiovascular parameters during induction of general Anaesthesia with Etomidate: A detailed pre anaesthetic ch
Sponsors
Maulana Azad medical college and associated Lok Nayak hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patients fulfilling the criteria for American society of Anaesthesiologist ,physical status 1-2 BMI less than 30 kg/m2
Exclusion criteria
Exclusion criteria: Hypertension, patient who have received corticosteroids in the last 6 months,pregnancy psychiatry illness or patients suffering from intellectual disabilities History of etomidate allergy History of psychoactive drugs Neurosurgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation of the induction dosage of etomidate during general anaesthesia with genetic polymorphism of GABRA2,CYP2C9,UGT1A9 and UGT1A7Timepoint: Baseline ,0 seconds ,30 seconds,60 seconds,90 seconds,120 seconds,150 secs ,180 secs | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) changes in the cardiovascular parameters during etomidate induction and correlating with generic polymorphisms of GABRA2,CYP2C9,UGT1A9,UGT1A7Timepoint: Baseline ,0 seconds ,30 seconds,60 seconds,90 seconds,120 seconds,150 seconds ,180 seconds | — |
Countries
India
Contacts
Public ContactDr Annam Lakshmanan
Maulana Azad Medical College and associated Lok Nayak hospital
Outcome results
None listed