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Comparison of blood flow to the brain using ultrasonography with two different methods of anesthesia induction in the elderly population

Comparison of corrected carotid flows after induction with propofol using Target controlled infusion versus Manual boluses in the elderly population undergoing General Anesthesia- A Randomized Controlled Trial - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/05/067093
Enrollment
106
Registered
2024-05-09
Start date
Unknown
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Target controlled infusion(TCI): This group patients will be given with propofol with initial effect site concentration of 2.5mcg/ml using schnider pharmacokinetic model, later 0.5mcg/m

Sponsors

AIIMS BHUBANESWAR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Elderly population of 60 years or greater and ASA 1/2 undergoing General Anesthesia with endotracheal intubation

Exclusion criteria

Exclusion criteria: 1) Patients who will refuse to participate in the study 2)BMI 30 or greater 3)Patients having egg allergy 4)DM with autonomic dysfunction 5)Patients with severe cognitive dysfunction 6)Patients with severe liver dysfunction 7)Patients in shock or coma patients or emergency cases 8)Preexisting tracheal intubation, tracheostomy or more than 1 attempt to intubate the patient 9)Patients with uncontrolled hypertension

Design outcomes

Primary

MeasureTime frame
To compare the change in corrected carotid flows(FTc) just after induction from the baeline with the propofol using Target controlled infusion versus manual boluses in the elderly population undergoing General AnesthesiaTimepoint: Preoperative period and intra operative period—

Secondary

MeasureTime frame
To determine the correlation of baseline corrected carotid flows (FTc) with post induction hypotension (PIH) in either group.Timepoint: Intraoperative period;To compare the incidence of PIH and time for onset of PIH among the groups.Timepoint: Intraoperative period;To compare FTc and other doppler parameters during hypotension in PIH subgroupTimepoint: Intraoperative period;To compare the time for induction and total dose of propofol used for induction among the groups.Timepoint: Intraoperative period;To compare the incidence of post operative delirium among the groupsTimepoint: Preoperative, intraoperative and within 5 days in postoperative period—

Countries

India

Contacts

Public ContactDr Kappa Venkata Anusha Sree

AIIMS Bhubaneswar

anaes_suma@aiimsbhubaneswar.edu.in7259000696

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026