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Observation of a Protein molecule in precancer diseases that may predict conversion into oral cancer

Chloride Intracellular Channel 4 Expression in Potentially Malignant Disorders, Verrucous Carcinoma and Squamous Cell Carcinoma of Oral Cavity: An Observational Study - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/05/067042
Enrollment
75
Registered
2024-05-08
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx

Interventions

Intervention1: Nil: Nil Control Intervention1: Nil: Nil

Sponsors

Institute of Dental Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Tissue samples of OPMDs that have been verified histopathologically 2 Tissue samples of OVC & OSCC that have been verified histopathologically

Exclusion criteria

Exclusion criteria: 1 Insufficient clinical data 2 Tissues where controls exhibit unexpected results 3 Tissue samples that do not contain enough biological material for an immunohistochemistry analysis to be done

Design outcomes

Primary

MeasureTime frame
Immunohistochemical expression for CLIC4 in Oral Potentially malignant disorders will be statistically low as compared to its expression in Oral verrucous carcinoma and Oral squamous cell carcinoma.Timepoint: Immunohistochemical staining expression will be evaluated Once only after CLIC4 staining procedure.—

Secondary

MeasureTime frame
NILTimepoint: NIL—

Countries

India

Contacts

Public ContactDr Madhusudan Astekar

Institute of Dental Sciences

madhu.tanu@gmail.com7599247899

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026