Health Condition 1: K650- Generalized (acute) peritonitis Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: 5% human albumin group: 5% human albumin used as
intraoperative fluid therapy (during the surgery/ anaesthesia)
Control Intervention1: Plasmalyte group: Plasmalyte used as intraoperativ
Sponsors
Sulagna Bhattacharjee
Eligibility
Inclusion criteria
Inclusion criteria: Patients with perforation peritonitis undergoing emergency laparotomy
Exclusion criteria
Exclusion criteria: 1. Patients refusal to participate in the study 2. Patients undergoing elective laparotomy 3. Pre-existing significant cardiac, renal and hepatic diseases 4. Intraoperative massive blood loss or massive transfusion 5. Patients who are on high dose of vasopressor (defined as noradrenalin 15mcg/min or equivalent).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the effect of 5% human albumin based perioperative fluid therapy on postoperative endothelial glycocalyx shedding product syndecan -1, as compared to isotonic balanced salt solutionsTimepoint: At the 24hours postoperative | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative hyaluronan, heparan sulphate, TNF- alpha, IL-1, IL-6 & IL-10 between two group of patients. 2. duration of ICU stay, hospital stay & mortality, incidence of postoperative pulmonary complications & acute kidney injury, requirement of postoperative mechanical ventilation between the two groups Timepoint: Postoperative 24hours | — |
Countries
India
Contacts
Public ContactSulagna Bhattacharjee
AIIMS, New Delhi
Outcome results
None listed