Comparison of nebulised fentanyl citrate and magnesium sulphate given before surgery on post-intubation blood pressure and heart rate in adults undergoing planned surgery.

Comparison of preoperative nebulised fentanyl citrate and magnesium sulphate on post-intubation hemodynamic response in adults undergoing elective surgery. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/066986

Enrollment

Registered

2024-05-08

Start date

Unknown

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nebulisation with fentanyl citrate: Nebulisation will be done once for 10mins with 5ml solution of NS and fentanyl @2micrograms per kg preoperatively Control Intervention1: Nebulisatio

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists physical status I and II, scheduled for elective surgeries under general anaesthesia requiring endotracheal intubation will be included in this study.

Exclusion criteria

Exclusion criteria: Hypersensitivity to two study drugs Anticipated difficult airway Body mass index = 30 kg/m2 History of reactive airway diseases, obstructive sleep apnea, hypertension and chronic drug abuse (narcotic) Pregnancy and lactation

Design outcomes

Primary

Measure	Time frame
To compare the changes in heart rate readings in the two groups, nebulised fentanyl citrate and magnesium sulphate. Timepoint: Baseline pre-nebulisation to 2 minutes post-intubation	—

Secondary

Measure	Time frame
To compare the changes in systolic blood pressure, diastolic blood pressure, and mean arterial pressureTimepoint: Baseline pre-nebulization to post-nebulization/ pre-induction, at the time of laryngoscopy, 1 minute, 2 minutes, 5 minutes, and 10 minutes post-intubation. ;To compare the heart rateTimepoint: at post-nebulisation, at the time of laryngoscopy, one minute, 5 minutes, and 10 minutes post-intubation time points.	—

Measure

Time frame

To compare the changes in systolic blood pressure, diastolic blood pressure, and mean arterial pressureTimepoint: Baseline pre-nebulization to post-nebulization/ pre-induction, at the time of laryngoscopy, 1 minute, 2 minutes, 5 minutes, and 10 minutes post-intubation. ;To compare the heart rateTimepoint: at post-nebulisation, at the time of laryngoscopy, one minute, 5 minutes, and 10 minutes post-intubation time points.

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Countries

India

Contacts

Public ContactDr Hemant

Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi

dr.pratiti@gmail.com9831081183

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026