Health Condition 1: C211- Malignant neoplasm of anal canal
Conditions
Interventions
Control Intervention1: NIL: NIL
Sponsors
Mahamana Pandit Madanmohan Malaviya Cancer Centre and Homi Bhabha Cancer Hospital, Varanasi
Eligibility
Inclusion criteria
Inclusion criteria: -Histological diagnosis of Squamous cell carcinoma of anal canal. -Patients being treated with curative intent with concurrent chemo- radiotherapy (CTRT) -Age of patient 18 years or older -ECOG status 0 – 2 -Patient consenting for participation in study (Written informed consent for prospective patients, Telephonic informed consent for retrospective patients)
Exclusion criteria
Exclusion criteria: -Unwilling to participate in the study. -Presence of distant metastases. -Medical condition precluding curative intent treatment for the patient. -History of previous treatment for current condition.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression of various molecular markers (p16, p53, PD-L1 and CAIX) in patients with anal cancer and correlate this with response to chemo-radiotherapy and treatment response rates at 6 months.Timepoint: 1.5 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Baseline expression of these moecular markers and their association with acute treatment toxicities based on RTOG toxicity criteria and disease status at 6 months. Also the prevalence of molecular markers in the study population. and association between presence of these molecular markers, patient and disease characteristics and disease outcomes. Timepoint: 1.5 Years | — |
Countries
India
Contacts
Public ContactDr Lincoln Pujari
Mahamana Pandit Madanmohan Malaviya Cancer Centre and Homi Bhabha Cancer Hospital
Outcome results
None listed