To compare the duration of postoperative analgesia in patients undergoing Laparoscopic cholecystectomy using Dexmedetomidine and Magnesium sulfate as adjuvants to Bupivacaine in Transversus Abdominis Plane block.

Comparison of Dexmedetomidine and Magnesium sulphate as adjuvant to Bupivacaine in ultrasound guided right oblique subcostal Transversus Abdominis Plane block for post operative analgesia in patients undergoing Laparoscopic cholecystectomy. - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/066934

Enrollment

Registered

2024-05-07

Start date

Unknown

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K768- Other specified diseases of liver

Interventions

Intervention1: Ultrasound guided right oblique subcostal transversus abdominis plane block: 18 ml 0.25% BUPIVACAINE + 1.5 ml ( 150 mg) magnesium sulphate + 0.5 ml normal saline. Total drug volume -

Eligibility

Inclusion criteria

Inclusion criteria: All Patients belonging to American Society of Anaesthesiologists(ASA) grade I and II and aged between 18–65 years of both genders, undergoing elective laparoscopic cholecystectomy with duration of surgery less than 2 hours are included in the stud

Exclusion criteria

Exclusion criteria: 1. History of allergy to drugs used in the study. 2. Infection or inflammation at the site of block application 3. Pregnant women 4. Those with a BMI of 30 and above. 5. Patients who have cognitive disability or unable to understand the VAS score.

Design outcomes

Primary

Measure	Time frame
To compare the duration of post operative analgesia (Time to first rescue analgesia as per Visual Analogue Scale for pain) using Magnesium sulphate and Dexmedetomidine as adjuvant to Bupivacaine in ultrasound guided right oblique subcostal Transversus Abdominis Plane Block in patients undergoing Laparoscopic Cholecystectomy.Timepoint: Post operatively at 0 hour , 1 hour, 2 hours, 6 hours, 12 hours, 24 hours	—

Measure

Time frame

To compare the duration of post operative analgesia (Time to first rescue analgesia as per Visual Analogue Scale for pain) using Magnesium sulphate and Dexmedetomidine as adjuvant to Bupivacaine in ultrasound guided right oblique subcostal Transversus Abdominis Plane Block in patients undergoing Laparoscopic Cholecystectomy.Timepoint: Post operatively at 0 hour , 1 hour, 2 hours, 6 hours, 12 hours, 24 hours

—

Secondary

Measure	Time frame
1. To determine the total amount of analgesics consumed in the initial 24 hours . 2. To evaluate changes in the hemodynamic parameters( Blood pressure and Heart rate) during intraoperative period and postoperative period over 24 hours. 3. To assess post operative sedation using Ramsay Sedation Score.Timepoint: Intra operatively and post operative period	—

Countries

India

Contacts

Public ContactDr Sujata Chaudhary

Vardhman Mahavir Medical College and Safdarjung Hospital

sujatac462@gmail.com9999051546

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026