FindTrial
Sign In

A Clinical study to find the effect of melatonin in reducing stress to intubation in patients undergoing surgeries.

To Study The Effect Of Preoperative Sublingual Melatonin In Attenuation Of Haemodynamic Stress Response To Laryngoscopy And Endotracheal Intubation In Patients Undergoing Elective Surgeries Under General Anaesthesia. - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/05/066842
Enrollment
62
Registered
2024-05-06
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Tablet Melatonin 6mg: Single sublingual dose of tablet melatonin 6mg one hour prior to surgery Control Intervention1: Placebo: Single sublingual dose of tpalcebo 6mg one hour prior to s

Sponsors

BGS Global Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients willing to give written informed consent. 2. ASA physical status I,II. 3. Patients posted for elective surgery under general anaesthesia with endotracheal intubation.

Exclusion criteria

Exclusion criteria: 1. Patients with anticipated difficult Intubation. 2. Patients with ASA physical status III and above. 3. Patients allergic to study drug. 4. Patients with steroids and antipsychotics. 5. Patients with history of active seizure disorders or active neurological disorders. 6. Patients with history of chronic alcoholism. 7. Patients with greater than 30kg per meter square.

Design outcomes

Primary

MeasureTime frame
To study the effect of preoperative sublingual melatonin 6mg on the pressor response by monitoring the hemodynamic changes to laryngoscopy and intubation.Timepoint: 1 hour before induction, immideately after intubation - 1min, 3min, 5min ,10 min and 15 minutes after intubation.—

Secondary

MeasureTime frame
To study the adverse effects of sublingual melatonin like dizziness and nausea.Timepoint: 2 hours—

Countries

India

Contacts

Public ContactDr Shilpa H L

BGS Global Institute of Medical Sciences

shilpahl@yahoo.com9916950558

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026