Health Condition 1: J441- Chronic obstructive pulmonary disease with (acute) exacerbation
Conditions
Interventions
Intervention1: magnesium sulphate: Patients of acute exacerbation of COPD in experimental group will receive intravenous infusion of 2gram of magnesium sulphate in 100ml of normal saline over 30 minu
Sponsors
All India Institute of Medical Sciences Bhubaneswar
Eligibility
Inclusion criteria
Inclusion criteria: All patient of AECOPD with following criteria’s a)pH less than 7.35, pCO2 more than 45 mm hg. or b)persistent hypoxemia despite supplemental oxygen therapy. [persistent hypoxemia that is patient not able to maintain more than 88% after 15 min of NRBM (15L per minute O2) or c)severe dyspnea with clinical signs suggestive of respiratory muscle fatigue, increased of work of breathing or both, such as use of respiratory accessory muscles paradoxical motion of the abdomen or retraction of intercostal spaces.
Exclusion criteria
Exclusion criteria: a)Patient with contraindication for use of mgso4 { hypersensitivity ,diabetic coma ,heart block, myocardial damage , dyselectrolytemia such as hypomagnesemia ,hypercalcemia) b) use of I.V. mgso4 in past 24 hours c)using medication that contain magnesium d)pregnant women e) pneumonia, pleural or pericardial effusion, pneumothorax, heart failure renal failure, sepsis. f) Haemodynamically unstable patient g) Patient requiring immediate endotracheal intubation. h) Uncooperative patient i) Did not consent to participate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Respiratory rate improvement 2. ABG parameters: arterial pH and pCO2 improvement. Timepoint: baseline, 1 hr,4hr,12hr,24hr | — |
Secondary
| Measure | Time frame |
|---|---|
| a)NIV failure rate and rate endotracheal intubation. b)Duration of NIV requirement in both groups. c)Length of hospital stay Timepoint: NIV failure rate and rate endotracheal intubationation at 24hour after start of treatment | — |
Countries
India
Contacts
Public ContactSADANANDA BARIK
AIIMS BHUBANESWAR
Outcome results
None listed