The effect of dexmedetomidine on the control of the brains blood flow in children, as assessed by doppler ultrasound of the blood vessels in the brain when under anaesthesia

Assessment of the effect of dexmedetomidine on dynamic cerebral autoregulation in children assessed with transcranial doppler under sevoflurane anaesthesia undergoing spine surgeries - NIL

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/066764

Enrollment

Registered

2024-05-03

Start date

Unknown

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Q070- Arnold-Chiari syndrome Health Condition 2: Q062- Diastematomyelia Health Condition 3: M411- Juvenile and adolescent idiopathicscoliosis Health Condition 4: Q057- Lumbar spina bifida without hydrocephalus Health Condition 5: C720- Malignant neoplasm of spinal cord Health Condition 6: O- Medical and Surgical Health Condition 7: G55- Nerve root and plexus compressionsin diseases classified elsewhere Health Condition 8: M414- Neuromuscular scoliosis Health Condition 9: Q063

Interventions

Intervention1: Dexmedetomidine infusion: Following induction of anaesthesia with sevoflurane, the patient will receive an infusion of dexmedetomidine as described in the protocol. The transcranial dop

Eligibility

Inclusion criteria

Inclusion criteria: Patients undergoing spine surgery under Motor Evoked Potential monitoring

Exclusion criteria

Exclusion criteria: 1)Age 14years 2)Patients with known allergy to any of the drugs used in the study (general anaesthetics, dexmedetomidine) 3)Disturbed intracranial dynamics that may affect TCD readings –untreated hydrocephalus, craniosynostosis

Design outcomes

Primary

Measure	Time frame
Transient Hyperaemic Response Ratio (THRR) measured from the right middle cerebral arteryTimepoint: measurements of THRR will be made 10 minutues after induction of anaesthesia, before the commencement of the surgery	—

Secondary

Measure	Time frame
Strength of Autoregulation(SA) will be calculated as a secondary outcomeTimepoint: Measurements will be taken 10 minutes after the induction of anaesthesia, & before the commencement of surgery	—

Countries

India

Contacts

Public ContactDr Madhumita R

Amrita Institute of Medical Sciences and Research Center, Kochi

mathew.doc@gmail.com9447841795

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026