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8-Isoprostane biomarker levels in patients with high blood pressure and pulp necrosis with symptomatic apical periodontitis

Gingival Crevicular Fluid Levels Of 8-Isoprostane In Hypertensive Patients Diagnosed With Pulp Necrosis And Symptomatic Apical Periodontitis:Cross Sectional Observational Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/05/066734
Enrollment
200
Registered
2024-05-03
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K044- Acute apical periodontitis of pulpal origin

Interventions

Control Intervention1: NIL: NIL

Sponsors

Chahat Singhal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients with relevant history of hypertension blood pressure in range of 140 to 159 mm Hg Systolic blood pressure and 90 to 99 mm Hg diastolic blood pressure i.e. Hypertension Grade I 2.Patients on medications for hypertension 3.Patients diagnosed with Pulp necrosis and Symptomatic Apical periodontitis according to AAE guidelines 4.Patients with OHI index of 0 and Russells Periodontal index not more than 0.9

Exclusion criteria

Exclusion criteria: 1.Patients having negative response to percussion testing 2.Patients with chronic periodontitis 3.Patients with any other underlying systemic diseases 4.Pregnant patients

Design outcomes

Primary

MeasureTime frame
There will be increased levels of 8 Isoprostane in hypertensive patients diagnosed with pulp necrosis and symptomatic apical periodontitis as compared to patients diagnosed with hypertension measured only at one point of time ie at time of sample collection.Timepoint: The levels of Biomarker 8-Isoprostane in gingival crevicular fluid will be measured only at time of Sample Collection.The estimation will be done at the time of sample collection.

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactChahat Singhal

Manav Rachna Dental College

sucheta.sds@mrei.ac.in7042643666

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026