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Utility of respiratory variation in peak aortic blood flow measured via suprasternal echocardiographic view for assessing fluid responsiveness in admitted patient with septic shock

Utility of respiratory variation in peak aortic flow under suprasternal echocardiography window for assessing preload responsiveness in septic shock - A prospective cohort trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/05/066696
Enrollment
140
Registered
2024-05-03
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R578- Other shock

Interventions

Intervention1: NIL: NIL

Sponsors

None
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with septic shock on invasive mechanical ventilation

Exclusion criteria

Exclusion criteria: 1. BMI more than 30 kg/m2. 2. Shock possibly attributed to other non-sepsis related causes. 3. Significant cardiovascular disease. 4. Increase in Intracranial Pressure 5. Patients of abdominal compartment syndrome. 6. Pregnant female 7. Refusal to participate in study.

Design outcomes

Primary

MeasureTime frame
T0 determine the thresholds, diagnostic profile, and level of agreement for the value of respiratory variation in peak descending aortic flow (?Vpeak dAo) and in Left ventricular outflow tract (?Vpeak LVOT) before PLR, in predicting preload responsiveness to passive leg raise test among critically ill mechanically ventilated patients presenting with septic shock.Timepoint: At T1- just before the passive leg raise test in semi-recumbent position At T2- 1 minute after the passive leg raise test with head end at zero degree.—

Secondary

MeasureTime frame
To determine the hemodynamic and echocardiography parameters including Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Arterial Pressure (MAP), SVI, and CI before and after PLR among responders and non-responders among critically ill mechanically ventilated patients presenting with septic shock.Timepoint: At T1- just before the passive leg raise test in semi-recumbent position At T2- 1 minute after the passive leg raise test with head end at zero degree;To compare the percentage change in hemodynamic and echocardiography parameters before and after PLR among responders and non-responders among critically ill mechanically ventilated patients presenting with septic shock.Timepoint: At T1- just before the passive leg raise test in semi-recumbent position At T2- 1 minute after the passive leg raise test with head end at zero degree.;To determine thresholds, diagnostic profile, and level of agreement for absolute and percentage change in ?Vpeak in descending aorta and in Left ventricular outflow tract before and after PLRTamong critically ill mechanically ventilated patients presenting with septic shock.Timepoint: At T1- just before the passive leg raise test in semi-recumbent position At T2- 1 minute after the passive leg raise test with head end at zero degree—

Countries

India

Contacts

Public ContactDr Gaurav Jain

All India Institute of Medical Sciences, Rishikesh

gauravhld@gmail.com8808631205

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026