NLRP3 biomarker levels before and after endodontic treatment in symptomatic apical periodontitis

Comparison of gingival crevicular fluid levels of NLRP3 in patients diagnosed with pulp necrosis and symptomatic apical periodontitis before and after endodontic treatment - NILL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/05/066690

Enrollment

Registered

2024-05-03

Start date

Unknown

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K044- Acute apical periodontitis of pulpal origin

Interventions

Intervention1: Root Canal Treatment: Non surgical root canal treatment in maxillary and mandibular molars. The levels of the biomarker NLRP3 shall be evaluated before and one week after completion of

Eligibility

Inclusion criteria

Inclusion criteria: Patients diagnosed with pulp necrosis and symptomatic apical periodontitis in a single tooth as per the clinical and pulp sensibility tests (according to the AAE guidelines) 2. Patients aged 18-40 years of age 3. Patients with no relevant medical history or absence of any systemic conditions 4. Non-smokers

Exclusion criteria

Exclusion criteria: 1. Patients with periodontitis 2.Patients with multiple carious teeth 3. Patients with apical abscess (swelling) &/or sinus tract

Design outcomes

Primary

Measure	Time frame
The NLRP3 levels in GCF may be increased and hence detectable in patients with Pulp Necrosis and Symptomatic Apical Periodontitis but will reduce after endodontic treatmentTimepoint: One week after completion of endodontic treatment.	—

Secondary

Measure	Time frame
N/ATimepoint: N/A	—

Countries

India

Contacts

Public ContactKarina

Manav Rachna Dental College

daxabraham.sds@mrei.ac.in9910433111

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026