Health Condition 1: F33- Major depressive disorder, recurrent Health Condition 2: F32- Major depressive disorder, singleepisode Health Condition 3: F34- Persistent mood [affective] disorders Health Condition 4: F20-F29- Schizophrenia, schizotypal, delusional, and other non-mood psychotic disorders
Conditions
Interventions
Intervention1: Ketamine hydrochloride i.v.
Infusion: Dose- 0.5 mg/kg ketamine hydrochloride diluted in 100 ml of 0.9% saline, infused intravenously over 40 minutes.
Frequency of intervention- Once in
Sponsors
Ashish Mishra
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adults aged 18-65 years 2. Primary diagnosis of Major Depressive Disorder or Schizophrenia Spectrum Disorder as per DSM-5 criteria 3. Score >=2 on Specific Loss of Interest and Pleasure Scale. 4. Remitted positive symptoms , defined as Score 5. Score
Exclusion criteria
Exclusion criteria: 1.Unstable Medical Condition (Diabetes, Hypertension, Coronary Artery Disease, Cerebrovascular Accident etc.) 2.Active Neurological Illnesses (Seizures, Parkinsonism, Stroke, History of Head Trauma etc.) 3.History of Hypersensitivity to Ketamine. 4.Active Substance Use in dependent pattern. 5.Active Suicidal risk. 6.History of receiving Long-acting Antipsychotic in last 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in score of Specific Loss of Interest and Pleasure ScaleTimepoint: 8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in score of other anhedonia subscales, EEfRT metrics of effort expenditure.Timepoint: 8 weeks | — |
Countries
India
Contacts
Public ContactAshish Mishra
Kalinga Institute Of Medical Sciences Bhubaneswar
Outcome results
None listed