Health Condition 1: O- Medical and Surgical Health Condition 2: J869- Pyothorax without fistula
Conditions
Interventions
Intervention1: VATS First: Group A: This group will first undergo VATS and then receive Streptokinase injection 24 hours post-VATS.
After randomization, patients will first undergo video-assisted tho
Sponsors
Rashi
Eligibility
Inclusion criteria
Inclusion criteria: Children aged 1 month to 15 years with a clinical diagnosis of Stage II or early-Stage III thoracic empyema. No previous use of Streptokinase. Pleural thickening less than 5 mm confirmed through USG and CECT Thorax. Presence of unilateral loculated pleural effusion with septation.
Exclusion criteria
Exclusion criteria: Known hypersensitivity or contraindications to Streptokinase. Children with a medical history of congenital vascular anomalies, hypoxic-ischemic encephalopathy, arteriovenous malformation, or bronchopleural fistula. Presence of other severe comorbidities or conditions of immunosuppression.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical resolution of symptoms such as fever and respiratory distress evidenced by the patient being afebrile for the last 24 hours and having ICD drainage of less than 15 ml in the last 24 hours. Radiological measures involving lung expansion, assessed through imaging at 6 and 48 hours post VATS. Minimal lung expansion should be 80%.Timepoint: 6 hours 24 hours 48 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to full resolution of empyema, measured in days post-intervention. Presence or absence of complications such as bleeding or other infections resulting from the Streptokinase injection. Length of hospital stay post-intervention. Any recurrence of empyema within a 6-month follow-up period.Timepoint: 6 months | — |
Countries
India
Contacts
Public ContactRashi
All India Institute of Medical Sciences Patna
Outcome results
None listed