Health Condition 1: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx
Conditions
Interventions
Intervention1: Not Applicable: Not Applicable
Control Intervention1: Not Applicable: Not Applicable
Sponsors
Tata Memorial Centre
Eligibility
Inclusion criteria
Inclusion criteria: -Individuals who are 18 years of age or above -Treatment naïve patients -Locally advanced Oral cancer patients -Those planned for Neoadjuvant Chemotherapy (NACT) as per the Joint Clinic decision will be included.
Exclusion criteria
Exclusion criteria: -Subjects failing these criteria will be excluded from the study -Patients where the biopsy will not be possible at the time of inclusion in study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -To carry out the IHC based analysis of the markers of, DNA damage or repair, hypoxia angiogenesis, apopotosis in tumor tissues before starting the therapy and at the time of surgery to evaluate the association with treatment response. -To carry out multiplex ELISA-based analysis of markers of inflammation, hypoxia, and angiogenesis before and after the treatment in serum samples and evaluate their association with clinical outcome. Timepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| -Quantitative and qualitative assessment of molecular markers and their relationship with clinical features and pathological prognostic factors. -To conduct the interactive analysis of different parameters that emerge as protective / risk factors that can serve as predictive markers for patient stratification. Timepoint: 3 years | — |
Countries
India
Contacts
Public ContactPoonam Joshi
Tata Memorial Centre
Outcome results
None listed