comparision of drug dexmedetomidine with mannitol drug on eye pressure and pressure in the brain on laparoscopic headdown surgeries

Comparison of Dexmedetomidine with Mannitol on Intraocular Pressure and Optic Nerve Sheath Diameter changes as a Surrogate Marker of Intracranial Pressure in Laparoscopic Trendelenburg Surgeries : A Randomised Double Blind Controlled Study - nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/066215

Enrollment

Registered

2024-04-24

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Inj Dexmedetomidine: Measurement of Intraocular pressure and optic nerve sheath diameter before induction in supine position and Inj Dexmedetomidine 0.5µg/kg loading dose followed by ad

Eligibility

Inclusion criteria

Inclusion criteria: Age 18 to 75 years old American Society of Anaesthesiologists (ASA) physical status I to II Laparoscopic Surgeries in Trendelenburg Position Duration of the Surgery more than 1 hour

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
To Compare the Effect of Dexmedetomidine and Mannitol on Intraocular Pressure and Optic Nerve Sheath Diameter in Patients undergoing Laparoscopic Trendelenburg SurgeriesTimepoint: In Supine Position before induction of Anaesthesia (T0) 10mins after insuffalation of Pneumoperitoneum (T1) 10mins after making the patient in Trendelenburg position (T2) 30mins after making the patient in Trendelenburg position (T3) 1hr after making the patient in Trendelenburg position (T4) In Supine Position Before Extubation (T5)	—

Measure

Time frame

To Compare the Effect of Dexmedetomidine and Mannitol on Intraocular Pressure and Optic Nerve Sheath Diameter in Patients undergoing Laparoscopic Trendelenburg SurgeriesTimepoint: In Supine Position before induction of Anaesthesia (T0) 10mins after insuffalation of Pneumoperitoneum (T1) 10mins after making the patient in Trendelenburg position (T2) 30mins after making the patient in Trendelenburg position (T3) 1hr after making the patient in Trendelenburg position (T4) In Supine Position Before Extubation (T5)

—

Secondary

Measure	Time frame
1. To Compare the Hemodynamic Changes in both the groups 2. To Compare the Side effect in both the group the groups Timepoint: In Supine Position before induction of Anaesthesia (T0) 10mins after insuffalation of Pneumoperitoneum (T1) 10mins after making the patient in Trendelenburg position (T2) 30mins after making the patient in Trendelenburg position (T3) 1hr after making the patient in Trendelenburg position (T4) In Supine Position Before Extubation (T5)	—

Measure

Time frame

1. To Compare the Hemodynamic Changes in both the groups 2. To Compare the Side effect in both the group the groups Timepoint: In Supine Position before induction of Anaesthesia (T0) 10mins after insuffalation of Pneumoperitoneum (T1) 10mins after making the patient in Trendelenburg position (T2) 30mins after making the patient in Trendelenburg position (T3) 1hr after making the patient in Trendelenburg position (T4) In Supine Position Before Extubation (T5)

—

Countries

India

Contacts

Public ContactDr Ashwin Kumar

Sri Manakula Vinayagar Medical College and Hospital

drpathin2@gmail.com9787740890

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026