Health Condition 1: C50-C50- Malignant neoplasms of breast Health Condition 2: O- Medical and Surgical Health Condition 3: R11- Nausea and vomiting
Conditions
Interventions
Intervention1: Group A: Amisulpride + Dexamethasone: Group A patients will receive IV Amisulpride 5 mg + Dexamethasone 4 mg
In addition, patients in group A will receive IV normal saline 2ml three ti
Sponsors
Dr Sohan Lal Solanki
Eligibility
Inclusion criteria
Inclusion criteria: 1. Female patients age more than 18 years 2. Post-chemotherapy breast cancer patients 3. Posted for mastectomy or breast conservative surgery including type 1 and type 2 onco-plasty 4. ASA I-III
Exclusion criteria
Exclusion criteria: 1. Consent refusal 2. Expected surgical duration more than 4 hours. 3. Patients with mental and cognitive dysfunction 4. Active smoker or history of smoking 5. History of allergy to amisulpride/ondansetron/dexamethasone 6. Patients with uncontrolled diabetes mellitis (HbA1c more than 8.5percent or Fasting Blood Sugar more than 180 mg/dl) 7. Patients with extrapyramidal disorders. 8. Patients with acute or chronic kidney disease. 9. Use of opioids, corticosteroids, psychoactive drugs or any other medication with known emetic or antiemetic effect within 24 hrs prior to surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall incidence of PONV between the two groupsTimepoint: Every half an hour for 2 hours in postanesthesia care unit and then in the ward at intervals of 2 to 6, 6 to 12 and 12 to 24 hours postoperatively | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the intensities of nausea and painTimepoint: Every half an hour for 2 hours in postanesthesia care unit and then in the ward at intervals of 2 to 6, 6 to 12 and 12 to 24 hours postoperatively | — |
Countries
India
Contacts
Public ContactRutuja Chavan
Tata Memorial Hospital
Outcome results
None listed