Effect of drug on extubation response given through nebulization preoperatively

Effect of pre-operative 0.5% Ropivacaine nebulization on extubation response in patients undergoing general anaesthesia - A Double blinded randomized controlled study. - Nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/066136

Enrollment

Registered

2024-04-23

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: 0.5% Ropivacaine: Patient will be administered 5ml of 0.5% Ropivacaine nebulization 5 to 10 minutes before induction of general anaesthesia. Control Intervention1: normal saline: Patien

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients between age groups 18 to 65 years and belonging to American society of Anesthesiologist physical status classification ASA-PS-I &II. 2. Patient scheduled for elective general anaesthesia procedures.

Exclusion criteria

Exclusion criteria: allergic to local anaesthetics

Design outcomes

Primary

Measure	Time frame
To compare the incidence and severity of cough between preoperative 0.5% Ropivacaine nebulization versus 0.9% normal saline nebulization in patients undergoing general anaesthesia with endotracheal intubation.Timepoint: Heart rate, Mean arterial pressure, spo2 will be recorded at baseline, upon tracheal intubation, every 1 minute till 5 minutes, Every 5 minutes after intubation till 20 mins, upon anaesthetic withdrawal, upon eye opening on verbal commands, upon tracheal extubation, immediately after extubation, every 5 minutes after extubation till 20 minutes. Incidence and severity of cough by Modified 4 point Minogue scale.	—

Measure

Time frame

To compare the incidence and severity of cough between preoperative 0.5% Ropivacaine nebulization versus 0.9% normal saline nebulization in patients undergoing general anaesthesia with endotracheal intubation.Timepoint: Heart rate, Mean arterial pressure, spo2 will be recorded at baseline, upon tracheal intubation, every 1 minute till 5 minutes, Every 5 minutes after intubation till 20 mins, upon anaesthetic withdrawal, upon eye opening on verbal commands, upon tracheal extubation, immediately after extubation, every 5 minutes after extubation till 20 minutes. Incidence and severity of cough by Modified 4 point Minogue scale.

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Secondary

Measure	Time frame
To compare perioperative hemodynamics, time to extubation, incidence and severity of sore throatTimepoint: Hemodynamics will be recorded at baseline,upon tracheal intubation,every 1 minute till 5 minutes,Every 5 minutes after intubation till 20 mins, upon anaesthetic withdrawal,upon eye opening on verbal commands, upon tracheal extubation every 5 minutes after extubation till 20 minutes. Sore throat recorded at 0,2,4,6 and 24 hrs.	—

Measure

Time frame

To compare perioperative hemodynamics, time to extubation, incidence and severity of sore throatTimepoint: Hemodynamics will be recorded at baseline,upon tracheal intubation,every 1 minute till 5 minutes,Every 5 minutes after intubation till 20 mins, upon anaesthetic withdrawal,upon eye opening on verbal commands, upon tracheal extubation every 5 minutes after extubation till 20 minutes. Sore throat recorded at 0,2,4,6 and 24 hrs.

—

Countries

India

Contacts

Public ContactMAHALAKSHMI

Pondicherry Institute of Medical Sciences

ramyavel1988@gmail.com9487630425

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026