Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: A single bolus dose of 0.1mg/kg morphine: Following induction and intubation,Patients will receive a single bolus dose of 0.1mg/kg morphine diluted to
10ml with normal saline.
Control
Sponsors
NIL
Eligibility
Inclusion criteria
Inclusion criteria: 1) Patients aged 18-65 years. 2) Patients coming under American Society of Anesthesiologists physical status28 I and II (Annexure IV). 3) Patients undergoing elective surgical procedures of expected duration of less than 4- hour requiring general anesthesia with endotracheal intubation.
Exclusion criteria
Exclusion criteria: 1)Patient refusal to give informed consent. 2)Patients with body mass index (BMI) > 30 kg/m2. 3)Patients with history of respiratory, cardiac, hepatic, renal and neuromuscular disorders. 4)Patients with chronic alcohol or drug abuse. 5)Patients being treated with rate controlling drugs, anticonvulsants or psychotropic medications. 6)Patients undergoing oro-naso pharyngolaryngeal surgeries. 7)Patients with anticipated difficult intubation. 8)Surgeries with expected duration more than 4 hours will be excluded. 9)Patients with history of allergy to the study drugs. 10)Pregnant or lactating mother.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the quality of extubation according to the 5-point extubation score.Timepoint: assessing the quality of extubation according to the 5-point extubation score at the time of extubation. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess Residual sedation.Timepoint: At the time of arrival in the post anesthesia care unit.;To assess Adverse cardiovascular effects (bradycardia, hypotension, tachycardia, hypertension, arrhythmias) in the peri-extubation period.Timepoint: The time interval from discontinuation of anesthetic agents to 15min after extubation.;To assess Level of agitation during emergence using Ricker sedation-agitation scale.Timepoint: assessing Level of agitation during emergence after tracheal extubation.;To assess Other complications (desaturation, laryngospasm, bronchospasm) in the post extubation period.Timepoint: The time interval from tracheal extubation to 15min after extubation.;To assess Pain score at arrival in the post anesthesia care unit (PACU).Timepoint: Pain score at the time of arrival in the post anesthesia care unit.;To assess Time to extubation. Timepoint: The time interval from discontinuation of anesthetic agents to tracheal extubation. | — |
Countries
India
Contacts
Public ContactDr R Sri Devi
Sri Venkateswara Institute of Medical Sciences
Outcome results
None listed