Efficacy of Ketofol (drug) for critically ill patients with liver disease.

Comparison of hemodynamics effects of Etomidate and Ketofol for endotracheal intubation in critically ill patients with liver disease: A randomized controlled trial. - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/066049

Enrollment

100

Registered

2024-04-22

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K721- Chronic hepatic failure

Interventions

Intervention1: Ketofol: Dose: 1- 2 mg/kg Frequency:once only Route of administration: intravenous Duration: One time only Control Intervention1: Etomidate: Dose: 0.2-0.3 mg/kg Frequency: once only Ro

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 18years or more 2. Advanced liver disease with MELDNa 15 or more 3. Undergoing elective endotracheal intubation

Exclusion criteria

Exclusion criteria: 1. Exclusion criteria: 2. Refusal to consent 3. Allergic to any of the agents being used 4. Pregnancy 5. Patients needing CPR 6. Patients with anticipated difficult airway 7. Acute liver failure

Design outcomes

Primary

Measure	Time frame
- To compare the incidence of post intubation hypotension occurring within 6 hours of intubation between etomidate and ketofol use for sedation during endotracheal intubations in liver ICUTimepoint: Within 6 hours	—

Secondary

Measure	Time frame
7-day mortalityTimepoint: first 7 days post intubation;Fall /Change in MAP from baseline for 1st 6 hours after intubationTimepoint: Within 6 hours post intubation;Incidence of post intubation hypertension within 6 hours of intubationTimepoint: Within 6 hours post intubation;Intubation difficulty scoreTimepoint: Day 0;Length of ICU stayTimepoint: 7 days;Number of days on ventilatorTimepoint: 7 days;Number of patients requiring vasopressors within 24 hrs of intubationTimepoint: within 24 hours post intubation;SOFA score at 1 hr and 24 hours post intubationTimepoint: 1 hr and 24 hrs after intubation;Total and peak dose of vasopressor requirement within 24 hrs post intubationTimepoint: within 24 hours of intubation	—

Measure

Time frame

7-day mortalityTimepoint: first 7 days post intubation;Fall /Change in MAP from baseline for 1st 6 hours after intubationTimepoint: Within 6 hours post intubation;Incidence of post intubation hypertension within 6 hours of intubationTimepoint: Within 6 hours post intubation;Intubation difficulty scoreTimepoint: Day 0;Length of ICU stayTimepoint: 7 days;Number of days on ventilatorTimepoint: 7 days;Number of patients requiring vasopressors within 24 hrs of intubationTimepoint: within 24 hours post intubation;SOFA score at 1 hr and 24 hours post intubationTimepoint: 1 hr and 24 hrs after intubation;Total and peak dose of vasopressor requirement within 24 hrs post intubationTimepoint: within 24 hours of intubation

—

Countries

India

Contacts

Public ContactDr. Shivali Panwar

INSTITUTE OF LIVER AND BILIARY SCIENCES

shivalipanwar@gmail.com9818241779

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026