Comparison of Salivary Alkaline Phosphatase levels during single step vs two step Twin Block in growing children

Comparative evaluation of Salivary Alkaline Phosphatase levels during single step vs two step mandibular advancement with Twin Block in growing children – A Randomized Clinical Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/066030

Enrollment

Registered

2024-04-19

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R930- Abnormal findings on diagnostic imaging of skull and head, not elsewhere classified

Interventions

Intervention1: Twin Block: Twin block treatment with single step advancement for 6 months Control Intervention1: Twin block: Twin block treatment with two step advancement for 6 months

Eligibility

Inclusion criteria

Inclusion criteria: Clinically No previous history of any orthodontic treatment. Each subject with a full cusp class II relationship bilaterally with convex facial profile. The overjet should be more than than 7 mm. VTO improved with anterior positioning of mandible. Radiographically: ANB angle more than 4 degrees with favourable growth pattern. Subjects who are at accelerated phase of pubertal growth spurt (CVMI stage-3), MP3-FG and MP3- G stage.

Exclusion criteria

Exclusion criteria: Syndromic cases. Children with following disorders – A) Disorders of Bone metabolism. B) Hepatobiliary disorders. C) Systemic Inflammatory diseases. Children with compromised oral hygiene. Children taking drugs that can alter salivary flow.

Design outcomes

Primary

Measure	Time frame
To Assess and compare the levels of salivary alkaline phosphatase during single step vs two step advancement of mandible using twin block in growing skeletal class II children.Timepoint: Baseline salivary ALP levels prior to twin block delivery, 1 month, 2months, 3 months, 4 months, 5 months, 6 months	—

Secondary

Measure	Time frame
1. Assess and compare skeletal and dentoalveolar effects of twin block therapy with a single step vs two step mandibular advancement. 2. Correlation of salivary alkaline phosphatase levels with skeletal effects. Timepoint: Every month for 6 months	—

Countries

India

Contacts

Public ContactPriyanka Badu

Government Dental College and Hospital Nagpur

wasundhara.bhad@gmail.com9890227819

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026