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A clinical trial to study the effect of platelet rich plasma on canine retraction in orthodontic patients.

Comparison Of mini-implant supported maxillary canine retraction with and without submucosal injection of autologous platelet rich plasma :A prospective ,single –blind ,split mouth randomized controlled trial. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/04/066015
Enrollment
18
Registered
2024-04-19
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Arushi Malhotra
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age range 16-25 years Critical anchorage Adequate interradicular distance between the maxillary first permanent molar and second premolar for insertion of mini screws. Good gingival and periodontal health (probing depth =3mm,gingival index score =1). No systemic disease Full development of teeth except 3rdmolars. Patients requiring bilateral extraction of maxillary 1st premolar as part of their comprehensive treatment. Platelet count above 100000/mL.

Exclusion criteria

Exclusion criteria: Clotting or bleeding disorders. Smokers, alcoholism Pregnancy Systemic disease or medications intake that interfere with orthodontic tooth movement or platelet count. Sign and symptom of periodontal disease. Gingival inflammation. (gingivitis) Poor oral hygiene for = 2 visits. History of previous orthodontic treatment. Dental caries. Long term use of antibiotics,phenytoin, cyclosporine,anti-inflammatory drugs, systemic corticosteroids and calcium channel blockers. Crossbite or deviation during jaw closure caused by occlusal interferences. Patient with severe tooth displacement (eg ectopic canine)

Design outcomes

Primary

MeasureTime frame
The predictor variable is the canine retraction technique i.e canine retraction with and without PRP injection. The canine retraction rate is our primary outcome.Timepoint: Base time point T0, then every monthly time point till four months i.e. T1, T2, T3, T4

Secondary

MeasureTime frame
Canine Rotations & molar rotations will be measured at monthly time intervals till 4 months from the base time pointTimepoint: base time point T0, then monthly intervals T1, T2, T3 & T4;Pain scores will be measured on VAS at base point, at 24 hours & after 7 daysTimepoint: base point, at 24 hours , after 7 days

Countries

India

Contacts

Public ContactArushi malhotra

Bhojia Dental college and hospital Bhud , Nalagarh

sanjaymtdr@yahoo.com09896050995

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026