Effectiveness of A-PRF and S-PRF on Postoperative Sequelae for Impacted Mandibular Third Molar Surgery

Comparative study on effects of A-PRF and S-PRF on pain edema trismus soft tissue healing and bone healing following impacted lower third molar extraction-A randomized control trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/065990

Enrollment

Registered

2024-04-19

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: A-PRF(Advanced-Platelet Rich Fibrin): A-PRF(Advanced -Platelet Rich Fibrin)in extracted third molar socket for 6 months Control Intervention1: S-PRF(Standard-Platelet Rich Fibrin): S-PR

Eligibility

Inclusion criteria

Inclusion criteria: 1.Healthy patients without significant medical diseases or a history of bleeding problems. 2.The third molars had to be in the Class I, Level A position (according to Pell &Gregory) 3.Impacted teeth to be in the mesioangular position according to Winter.

Exclusion criteria

Exclusion criteria: 1.Pregnant and lactating women 2.Patients with signs of pericoronitis 3.Patients with chronic use of medications such as antihistamines, non steroidal anti inflammatory drugs (NSAID, steroids and antidepressants which would complicate the evaluation of their postoperative response.

Design outcomes

Primary

Measure	Time frame
1.Postoperative pain will be measured using a visual analogue scale (VAS). 2.Soft tissue healing will be assessed based on Landry and Turnbull scale. 3.Trismus will be evaluated by measuring the distance between incisal edges of upper and lower central incisor at maximal mouth opening. 4.Bone healing of the third molar socket will be assessed radiographically using an OPG/IOPAR. 5.Post-operative swelling will be assessed. Timepoint: 1.Post Operative pain will be assessed at day 1, day 3 and day 7. 2.Post Operative swelling will be assessed at day 1, day 3 and day 7. 3.Post Operative trismus will be assessed at postoperative day 1, day 3 and day 7. 4.Soft tissue healing will be assessed on Postoperative Day 7. 5.Bone healing radiographically will be assessed on postoperative 1 month, 3 months and 6 months	—

Measure

Time frame

1.Postoperative pain will be measured using a visual analogue scale (VAS). 2.Soft tissue healing will be assessed based on Landry and Turnbull scale. 3.Trismus will be evaluated by measuring the distance between incisal edges of upper and lower central incisor at maximal mouth opening. 4.Bone healing of the third molar socket will be assessed radiographically using an OPG/IOPAR. 5.Post-operative swelling will be assessed. Timepoint: 1.Post Operative pain will be assessed at day 1, day 3 and day 7. 2.Post Operative swelling will be assessed at day 1, day 3 and day 7. 3.Post Operative trismus will be assessed at postoperative day 1, day 3 and day 7. 4.Soft tissue healing will be assessed on Postoperative Day 7. 5.Bone healing radiographically will be assessed on postoperative 1 month, 3 months and 6 months

—

Secondary

Measure	Time frame
The presence of alveolar osteitis will be assessed on the basis of clinical examination and subjective symptoms reported by the patient.Timepoint: Assessment for alveolar osteitis will be done clinically at postoperative day 3 and 7.	—

Countries

India

Contacts

Public ContactMAMTHASHRI

GOVERNMENT DENTAL COLLEGE AND RESEARCH INSTITUTE ,BANGALORE

mamthashri15@gmail.com9972888088

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026