Health Condition 1: E039- Hypothyroidism, unspecified
Conditions
Interventions
Intervention1: Levothyroxine: Levothyroxine will be given once weekly for 12 weeks
Control Intervention1: Levothyroxine: Levothyroxine will be given once daily for 12 weeks.
Sponsors
All India Institute of Medical Sciences Jodhpur
Eligibility
Inclusion criteria
Inclusion criteria: 1.Known case of Primary Hypothyroidism 2.Patients willing to give written informed consent
Exclusion criteria
Exclusion criteria: 1.Pregnancy and lactating women 2.Patients requiring Levothyroxine dose more than 150 mcg or less than 25 mcg 3.Critical care illness requiring hospitalization in ICU 4.Known cases of pituitary disorders 5.Women currently on Oral Contraceptives Pills or planning to take OCPs 6.Chronic Kidney disease patients with serum creatinine more than 1.8 7.Known cases of nephrotic syndrome 8.All patients diagnosed with Rheumatoid Arthritis 9.Patients with TSH more than 20 milli international unit per liter
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To compare the change in thyroid hormone (T3, T4, TSH) levels between two groupsTimepoint: Baseline and 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the adverse events between two treatment groupsTimepoint: Baseline and 12 weeks;To compare the laboratory parameters namely LDL, hsCRP, CBC, Urinary protein and NT-pro BNP in two study groups.Timepoint: Baseline and 12 weeks;To compare the mean change in Quality-of-Life scores (SF-36 scaling tool) from baseline to 12 weeks.Timepoint: Baseline and 12 weeks | — |
Countries
India
Contacts
Public ContactDr Sanchi Sukhija
Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur
Outcome results
None listed