Preoperative Dexmedetomidine Nebulization Vs Lignocaine and normal saline Nebulization to Blunt Stress Response To Laryngoscopy And Intubation

A Comparative Study To Evaluate The Effects Of Preoperative Dexmedetomidine Nebulization Vs Lignocaine and normal saline Nebulization On The Hemodynamic Response To Laryngoscopy And Intubation

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/065959

Enrollment

Registered

2024-04-19

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: laryngoscopy and intubation: To see Effect on the hemodynamic response to laryngoscopy and intubation with preoperative Dexmedetomidine nebulization vs Lignocaine and normal saline nebu

Eligibility

Inclusion criteria

Inclusion criteria: Patient undergoing elective surgeries requiring general anesthesia and tracheal intubation and Belonging to ASA grade 1 2 and 3

Exclusion criteria

Exclusion criteria: Patients unwilling to participate Patients with renal hepatic cardiovascular or respiratory diseases belonging to ASA grade 4 or more Pregnant and lactating women Patient with history of allergy to dexmedetomidine and lignocaine Patient with sore throat dry cough local factors in nose and mouth pre operatively

Design outcomes

Primary

Measure	Time frame
To prevent hemodynamic stress response to laryngoscopy and intubationTimepoint: At the time of incision at 0 minute and post extubation	—

Secondary

Measure	Time frame
To see if lesser amount of propofol is requiredTimepoint: During laryngoscopy and intubation	—

Countries

India

Contacts

Public ContactDr Hardikkumar Manilal Makwana

Pramukh swami medical college

hardikmakwana19021997@gmail.com8758922773

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026