A comparative study between two different drugs, Magnesium, and Zinc to find out their effect in reducing post-operative sore throat after general anesthesia.

Efficacy and Safety of Oral Magnesium vs. Oral Zinc in the Post-Operative Sore Throat (POST): A Prospective, Randomized, Double-blind, Placebo-Controlled Study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/065839

Enrollment

120

Registered

2024-04-16

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Zinc and magnesium: Zinc and magnesium supplements will be compared with placebo for prevention of post operative sore throat after general anaesthesia Control Intervention1: Placebo: P

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I and II

Exclusion criteria

Exclusion criteria: 1) History of preoperative sore throat, common colds, upper respiratory infections, immune deficiencies 2) Chronic smokers 3) Patients with Mallampati airway grade of more than 2 4) Patients requiring more than one attempt for intubation or traumatic intubations 5) Patients requiring laryngeal mask Airway (LMA) placement 6) Patients allergic to zinc or magnesium 7) Patients undergoing head and neck surgeries 8) Pregnancy

Design outcomes

Primary

Measure	Time frame
Occurence of POST at 4 hours.Timepoint: Occurence of POST at 4 hours.	—

Secondary

Measure	Time frame
Severity of POST at 0, 2 & 24 hours after the surgery. Number of adverse effects in all three groups also recorded in secondary outcome.Timepoint: Till 24 hour post surgery	—

Countries

India

Contacts

Public ContactDr Sumit Bansal

AIIMS, Rajkot

sumitbansal05@gmail.com9968720446

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026