Health Condition 1: G248- Other dystonia
Conditions
Interventions
Intervention1: Repetitive transcranial magnetic stimulus. SHAM and REAL alternatively.: In this crossover study, 50 patients with task specific FHD will be randomized to receive 5
daily sessions of e
Sponsors
Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria-Patients meeting all of the following criteria will be included in the study: a) Diagnosis of isolated, task specific focal hand dystonia as per MDS consensus update on phenomenology and classification of dystonia1 by 2 independent movement disorder specialists.b) Age 18-60 years2 .c) Not received BONT injections in the past 4 months.d) No localscalp infections/ wounds e) Able to give informed consent.
Exclusion criteria
Exclusion criteria: .3. Exclusion criteria Participants meeting any of the following the criteria will be excluded from the study a) History of brain tumour, stroke, traumatic brain injury, epilepsy or seizure in lifetime. b) History of major depression, psychosis c) Implanted pacemaker, intracardiac lines, pumps or stimulators, or metallic foreign bodies inside the eye or skull. (Dental fillings and braces are allowed) d) Pregnancy (negative UPT in 2 weeks) Age and gender matched Healthy volunteers, with no known neurological complaints will be included for validation of fMRI, electrophysiology and kinematic protocols.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be the Writer’s Cramp Rating Scale (WCRS) immediately after the intervention session.Timepoint: The primary outcome will be the Writer’s Cramp Rating Scale (WCRS) immediately after the intervention session. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes will include kinematic analysis (accelerometry, goniometry, handwriting kinematics), patient global impression of change scale, resting and task based functional MRI assessments.Timepoint: 1day | — |
Countries
India
Contacts
Public ContactDeblina Biswas
AIIMS, New Delhi
Outcome results
None listed