Skip to content

Is Cognitive Rehabilitation Effective in Improving Cognition and Quality of Life of Patients with Chemotherapy-Related Cognitive Issues

Effectiveness of Cognitive Rehabilitation on Cognition and Quality of Life in Chemotherapy-Induced Cognitive Impairment- A Randomized Control Trial. - NIL

Status
Active, not recruiting
Phases
Phase 1Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/04/065805
Enrollment
60
Registered
2024-04-16
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D499- Neoplasm of unspecified behavior of unspecified site

Interventions

Intervention1: Aerobic Exercises and Cognitive rehabilitation: After identifying the cognitive impairment, cognitive rehabilitation and aerobic exercises will be given for the duration of 45 minutes w
chunking is a process of taking individual pieces of information (chunks) and grouping them into large units
the method of memory enhancement uses visualizations with the use of spatial memory
story recall is when reading or listening to a story
it might be helpful to focus on only the key points of the story, this way irrelevant information can be forgotten and the story may simplify and be easier to recall and in last recall the list of thi
spaced retrieval helps to aid increase retention of information. This strategy is beneficial for face-name associations, object naming, memory of object location, face-name recall, and presenting a ph

Sponsors

Ravi Nair Physiotherapy College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Newly diagnosed patients with stages I to III cancers planning to receive a definitive number of platinum-based compounds chemotherapy. 2) Patients who are given Taxanes and Platinum-based compounds – Cisplastin, Carboplatin and Oxaliplatin 3) 3) Patients having Grade I or II cognitive impairment according to National Cancer Institute –common toxicity criteria. 4) Planned to receive a minimum of 4 cycles of chemotherapy treatment with either of the chemotherapy agents (Platinum based compound) 5) Both Male and female aged grouped between 14-70 years. 6) Patients who are given drugs according to approval of national cancer board

Exclusion criteria

Exclusion criteria: 1) Patients having Pre-existing cognitive impairment. 2) Patient having Traumatic Brain Injury. 3) Patients having a previous history of any psychological condition that could impair cognitive function. 4) Patients who did not perceive any chemotherapy cycle after cancer treatment. 5) Patients with a previous history of cancer and chemotherapeutic drugs. 6) Those who were having any neurological disorders in the brain and spinal cord such as Alzheimer’s disease (AD), Lewy body disease, stroke (CVA), Huntington’s disease, MS, ALS, frontotemporal dementia, and vascular dementia; use of medication known to have a negative impact on cognition (benzodiazepines). 7) Use of antipsychotics and cholinesterase inhibitors (CHEIs); current or recent (past 6 months) alcohol or substance use disorder; any behavioural changes like depression, anxiety, stress, other systemic diseases likely to impair cognition, such as hypothyroidism, de ?ciency of folic acid or vitamin B12, or viral infection (syphilis, HIV); vision and speech impairment (aphasia).

Design outcomes

Primary

MeasureTime frame
1.Mini Mental State Examination 2.Montreal Cognitive Assessment 3.Functional Assessment of Cancer Therapy CognitiveTimepoint: Baseline data will be collected and data analysis will be done after 4 weeks

Secondary

MeasureTime frame
1. European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 2. Patient Specific Functional ScaleTimepoint: Baseline data will be collected and data analysis will be done after 4 weeks

Countries

India

Contacts

Public ContactDr. Moh’d Irshad Qureshi

Ravi Nair Physiotherapy College Datta Meghe Institute of Higher Education and Research

irshadphysio@rediffamail.com9406010010

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026