comparing efficacy of preoperative magnesium sulphate nebulization with ketamine nebulization in reducing incidence of severity of post operative sore throat in patient undergoing surgery under general anesthesia.,

To study and compare the efficacy of preoperative Magnesium Sulphate nebulization with Ketamine nebulization In reducing the incidence and severity of post-operative pharyngolaryngeal complications - A prospective triple blinded randomised controlled Study - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/065794

Enrollment

Registered

2024-04-16

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Patients are randomly selected and Nebulized with magnesium sulphate 250mg and ketamine 50mg for 15 mins before surgery. Patients are then followed up for developing pharnygolaryngeal

Eligibility

Inclusion criteria

Inclusion criteria: 1.Males and females between the age group 18-60 years. 2. ASA class I-II. 3. Body mass index(BMI) 18.5-29.9. 4. Undergoing surgeries requiring general anaesthesia with cuffed ETT of duration 60-120 minutes.

Exclusion criteria

Exclusion criteria: 1. Patient’s refusal participation in study. 2. Haemodynamically unstable patients. 3. History of hypertension, asthma, chronic obstructive pulmonary disease(COPD), cardiovascular disease, renal disease, diabetes mellitus, cerebrovascular disease. 4. Patients having known hypersensitivity to drugs under consideration. 5. Patient with three or more attempts at laryngoscopy or bougie for intubation. 6. Patients who sustained trauma while intubation or nasogastric tube insertion as evidenced by blood on cuff after extubation or blood stained secretions while suctioning before extubation. 7. Patient suffering from active or recent (past 6 weeks) upper airway tract infection (preoperative sore throat, cough) and edema/inflammation noticed during laryngoscopy. 8. Surgery requiring placement of nasogastric tube intraopeartively. 9. Patients already on analgesics or steroids (systemic or inhaled).

Design outcomes

Primary

Measure	Time frame
PRIMARY OBJECTIVES 1. To Evaluate & compare the effectiveness of nebulised Magnesium sulfate & ketamine in: a. Extubation Quality using 5 point extubation quality score. b. Post extubation airway related adverse effects like cough (POC), sore throat (POST) & hoarseness (POH). SECONDARY OBJECTIVES 1. To access the haemodynamic parameter during surgery & extubation. 2. To access the airway dynamics during surgery & extubation. 3. To study side effect of study drugs if any. 4. Patient satisfaction score.Timepoint: 2,4,6,12,24,48 hours	—

Measure

Time frame

PRIMARY OBJECTIVES 1. To Evaluate & compare the effectiveness of nebulised Magnesium sulfate & ketamine in: a. Extubation Quality using 5 point extubation quality score. b. Post extubation airway related adverse effects like cough (POC), sore throat (POST) & hoarseness (POH). SECONDARY OBJECTIVES 1. To access the haemodynamic parameter during surgery & extubation. 2. To access the airway dynamics during surgery & extubation. 3. To study side effect of study drugs if any. 4. Patient satisfaction score.Timepoint: 2,4,6,12,24,48 hours

—

Secondary

Measure	Time frame
SECONDARY OBJECTIVES 1. To access the haemodynamic parameter during surgery and extubation. 2. To access the airway dynamics during surgery and extubation. 3. To study side effect of study drugs if any. 4. Patient satisfaction score. Timepoint: 2,4,6,12,24,48hours	—

Countries

India

Contacts

Public Contactshivakumar kala vaishnav krishna

Dr Rajendra Prasad Governent Medical College Tanda,Kangra.

bhanurpgmc@gmail.com9418016807

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026