Health Condition 1: O429- Premature rupture of membranes, unspecified as to length of time between rupture and onset of labor
Conditions
Interventions
Intervention1: Cefuroxime and azithromycin: Patients giving informed written consent with singleton pregnancy with diagnosis of PPROM after 24 weeks and before 37 WEEKS will be randomized into 2 group
Sponsors
DrJyoti
Eligibility
Inclusion criteria
Inclusion criteria: – Patient giving written informed consent – Singleton pregnancy, PPROM after 24 weeks of gestation & before 37 weeks.
Exclusion criteria
Exclusion criteria: -Not giving consent – Conditions requiring expedite delivery or contraindication of conservative management like: Chorioamnionitis Fetal distress Placental abruption Active labour
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Latency period Early neonatal sepsis rate-positive blood culture Chorioamnionitis rate Timepoint: Latency period-date of randomisation until date of delivery Early neonatal sepsis rate- within 3 days of delivery Chorioamnionitis rate-from day of randomisation until date of clinical/laboratory Chorioamnionitis diagnosis assessed up to 10 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Neonatal weight Apgar score Neonatal intensive care unit (NICU) admission durationTimepoint: Neonatal weight [ Time Frame: at delivery] grams Apgar score [ Time Frame: 1 minute - 5minutes] score from 0 to 10 Other Neonatal intensive care unit (NICU) admission duration [Time Frame: days since delivery until rerelease from NICU, assessed up to 6 months] | — |
Countries
India
Contacts
Public ContactDr Jyoti
KING GEORGES MEDICAL UNIVERSITY, LUCKNOW
Outcome results
None listed