A study comparing the effects of two different doses of intravenous Dexmedetomidine (0.5 mcg/kg and 1 mcg/kg) on changes in heart rate and blood pressure during removal of endotracheal tube in abdominal surgeries.

Comparison on the effect of two different doses of I.V Dexmedetomidine (0.5 mcg/kg and 1 mcg/kg) on haemodynamic responses during tracheal extubation following abdominal surgeries. - Nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/065697

Enrollment

120

Registered

2024-04-15

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Infusion Dexmedetomidine (0.5 microgram per kilogram of body weight): Infusion Dexmedetomidine is given at a dose of 0.5 microgram per kilogram of body weight over a period of 15 minut

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria:- 1.18 -45 years in both sex. 2.ASA grade I and II 3.Elective Abdominal Surgeries

Exclusion criteria

Exclusion criteria: 1.Active upper respiratory tract infections. 2.Known case of drug allergy. 3 Patients with respiratory dysfunction and obstructive sleep apnea. 4.Patients who are obese.

Design outcomes

Primary

Measure	Time frame
To determine whether Dexmedetomidine 0.5 microgram per kilogram body weight or Dexmedetomidine 1 microgram per kilogram body weight is more effective in attenuating haemodynamic responses like heart rate, mean arterial pressure,systolic blood pressure and diastolic blood pressure during extubation in abdominal surgeries.Timepoint: Outcomes mentioned above will be measured at 0 mins, 1 min, 3 mins, 5 mins, 10 mins, 15 mins, 20 mins, 25 mins and 30 mins.	—

Measure

Time frame

To determine whether Dexmedetomidine 0.5 microgram per kilogram body weight or Dexmedetomidine 1 microgram per kilogram body weight is more effective in attenuating haemodynamic responses like heart rate, mean arterial pressure,systolic blood pressure and diastolic blood pressure during extubation in abdominal surgeries.Timepoint: Outcomes mentioned above will be measured at 0 mins, 1 min, 3 mins, 5 mins, 10 mins, 15 mins, 20 mins, 25 mins and 30 mins.

—

Secondary

Measure	Time frame
To compare the effects of Dexmedetomidine 0.5 mcg/kg ,1 mcg/kg and placebo on extubation quality score.Timepoint: To assess the extubation quality score between all the groups from extubation to every 5 mins up to 30 mins after extubation.	—

Countries

India

Contacts

Public ContactDr Abhijit Das

Silchar Medical College and Hospital

adasdr14@gmail.com9401000010

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026