To Assess the Efficiency of local Application of Vancomycin powder, alongside standard intravenous antibiotics in patients undergoing Total Hip and Knee Replacement surgeries through a Randomized Controlled Trial.

Randomized Controlled Trial of Intrawound application of Vancomycin powder in Total Hip and Knee Arthroplasty as compared with standard postoperative antibiotics in preventing postoperative infections. - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/04/065612

Enrollment

Registered

2024-04-12

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Trial Group: Intrawound Application of Vancomycin along with postoperative antibiotics: 1 gram of Vancomycin is mixed with Normal saline and used for surgical site lavage and 1 gram of

Eligibility

Inclusion criteria

Inclusion criteria: All individuals aged 18 years or older who have been admitted in JSS Hospital, Mysuru and are undergoing elective THR, TKR will be used.

Exclusion criteria

Exclusion criteria: 1) Patients with sepsis, hemodynamic instability or displayed signs of active infection(septic arthritis) 2)Patients with a known allergy to Vancomycin (itchiness, swelling, anaphylactic reaction). 3)Patients undergoing revision THR and Revision TKR. 4)Patients who are immunocompromised. 5)Patients who had previous surgery or history of radiation therapy at the surgical site.

Design outcomes

Primary

Measure	Time frame
To evaluate the efficacy of local application of Vancomycin powder in preventing Surgical Site Infections in patients undergoing Total Hip Replacement and Total Knee Replacement SurgeriesTimepoint: The time points during which the patients would be assessed are preoperatively, postoperative period (2nd, 5th and tenth day), 2nd week, 6th week, 3rd month, 6th month and 1 year after surgery.	—

Secondary

Measure	Time frame
To assess the adverse effects of intrawound application of Vancomycin PowderTimepoint: Postopertive period, 2nd week, 6th week, 3rd month, 6th month and 1 year after surgery.	—

Countries

India

Contacts

Public ContactDr Siddalingamurthy G

JSS Medical College and Hospital, Mysore

siddalingamurthyg@jssuni.edu.in9901273360

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026