Health Condition 1: K120- Recurrent oral aphthae
Conditions
Interventions
Intervention1: Capsule Cholecalciferol 60,000 IU: 33 subjects will be prescribed 2% lignocaine anesthetic Gel along with weekly administration of Vitamin D3 (Cholecalciferol) 60,000 IU for 8 weeks and
Sponsors
Government Dental College and Research Institute Bangalore
Eligibility
Inclusion criteria
Inclusion criteria: Subjects aged 18 to 60 years of both genders, diagnosed according to Major and Minor Diagnostic criteria of Recurrent Aphthous Stomatitis as given by Natah et al in 2004. All four major and one minor criterion are to be fulfilled for diagnosis of RAS. Subjects with Serum Vitamin D less than 30 ng/ml who voluntarily consented to be a part of the study
Exclusion criteria
Exclusion criteria: Subjects having received any systemic medication for Recurrent Aphthous Stomatitis(RAS) in the last three months. Subjects with history of use of vitamin D supplements in a general multivitamin, along with calcium supplements or antioxidants or have already received Vitamin D3 as a treatment for another underlying disease at the time of the start of our study. Subjects who were taking any drug affecting TNF-alpha levels or vitamin D metabolism in past six months. Subjects with history of known allergy to vitamin D supplements Subjects with any systemic disease affecting vitamin D metabolism. Subjects with any oral ulcers other than RAS minor. Habit of smoking Pregnant and lactating females
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical parameters assessed are Number of ulcers of Recurrent Aphthous Stomatitis Size of ulcers of RAS Frequency of RAS Healing Time of RAS VAS scoreTimepoint: Baseline, 8th week, 12 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum TNF-alpha levels at Baseline and at the end of eight weeks of oral Vitamin D3 supplementationTimepoint: Baseline and 8th week;Serum Vitamin D levels at Baseline and at the end of eight weeks and 12 months of oral Vitamin D3 supplementationTimepoint: Baseline, 8th week, 12 months | — |
Countries
India
Contacts
Public ContactDr Revanth Rao E
Government Dental College and Research Institute Bangalore
Outcome results
None listed